Mesto bisfosfonatov pri zdravljenju bolnikov z rakom Biphosphonates in the treatment of breast cancer patients

Povzetek

Pri bolnikih z rakom in zasevki v kosteh je veliko tveganje za razvoj zapletov v kosteh, kar vodi v razvoj bolečin, patoloških zlomov, kompresije spinalnega kanala, hiperkalcemije in napredujoče nepokretnosti, zaradi česar se slabša kakovost življenja. Bisfosfonati preprečijo, zmanjšajo in odložijo te zaplete. Zaradi uvedbe teh zdravil so zapleti med bolniki z zasevki v kosteh bistveno redkejši. Znanih je tudi čedalje več izsledkov, ki kažejo na vlogo bisfosfonatov v preprečevanju izgube kostne mase med zdravljenjem raka. Danes poznamo vrsto bisfosfonatov, ki se razlikujejo po moči, učinkovitosti, odmerjanju, načinu dajanja in po odobrenih indikacijah za zdravljenje.

Abstract (Eng)

Cancer patients suffering from bone metastases are at increased risk for skeletal complications, which contributes to increased morbidity and have a negative effect on patients' quality of life. Bisphosphonates prevent, reduce, and delay cancer-related skeletal complications in patients, and have substantially decreased the prevalence of such events since their introduction. In addition, the results of clinical trials investigating the efficacy of bisphosphonates in cancer-treatment bone loss have been recently published. Today, a broad range of bisphosphonates with differences in potency, efficacy, dosing, and administration as well as approved indications is available.