Primer bolnika z nevrološkimi simptomi 11 let po zdravljenju karcinoma testisa The patient with neurologic symptoms appearing 11 years after treatment of testicular cancer

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Abstract (Eng)

Introduction of cisplatin-based chemotherapy (ChT) improved the cure rate of patients with testicular cancer. Polyneuropathy, as the most common side effect of cisplatin, is observed in a high proportion of patients treated with PVB. Peripheral nerve damage of different grade, depending on the cumulative dose of the drug may last for many years after the conclusion of treatment. A large study on neuro-toxic symptoms in subjects treated with 6 cycles PVB is quoted. In the presented patient, neurologic symptoms appeared 11 years after the treatment with 3 cycles of PVB. The cause of his symptoms is not clear. Years ago, radiation was recognized as the most frequent cause of late effects, with chemotherapy recently increasing its role in this process. Careful life time follow-up by assorted specialists is necessary to gain further experience.