Zdravljenje bolnikov s karcinozo peritoneja s HIPEC Perioperative management of patients with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)

an anesthesiologist's point of view

Abstract

Bolnik s peritonealno karcinozo, zdravljen s sistemsko kemoterapijo, ima slabo napoved in preživetje nekaj mesecev. V zadnjih letih je postala hipertermična intraperitonealna kemoterapija (HIPEC) po popolni kirurški odstranitvi tumorja možen način zdravljenja karcinoze peritoneja, ki znatno podaljša preživetje bolnikov z območno napredovalo obliko več vrst tumorjev. Opisani so perioperativno anesteziološko vodenje bolnikov in značilnosti prvih 11 posegov s HIPEC, opravljenih na Onkološkem inštitutu v Ljubljani v preteklem letu.

Abstract (Eng)

The diagnosis of peritoneal carcinomatosis is often associated with poor prognosis and a median survival of a few months, depending on the primary tumor. Hyperthermic intraperitoneal chemotherapy (HIPEC) after complete surgical resection is currently accepted as a therapeutic option for peritoneal carcinomatosis and it considerably prolongs the survival in several tumor types with peritoneal spread. Perioperative anaesthetic management of the patients undergoing such procedure is described and characteristics of the first 11 HIPEC procedures, performed at the Institute of Oncology Ljubljana in 2009, are presented.