Prizadetost srca po obsevanju in kemoterapiji Hodgkinove bolezni Cardiac damage in patients treated for Hodgkin's disease with radiotherapy and chemotherapy

case report

Abstract

Po zdravljenju Hodgkinove bolezni z obsevanjem in kemoterapijo v otroštvu se lahko šele čez leta pojavijo posledice na srcu. Pri predstavljenem bolniku smo 25 let po zdravljenju ugotovili spremembe na srcu, ki so se med desetletnim opazovanjem stopnjevale. Ugotovili smo prizadetost diastolične funkcije levega srčnega prekata, fibrozo na aortni in mitralni zaklopki ter zadebelitev osrčnika. Pri mladostnikih, ki so se v otroštvu zdravili zaradi raka, je potrebno sledenje poznih posledic do konca življenja. Večino neugodnih posledic na srcu lahko odkrijemo z neinvazivno ehokardiografsko preiskavo.

Abstract (Eng)

Cardiac damage can develop many years after treatment of Hodgkin’s disease with irradiation and chemotherapy. In the presented case, we found cardiac damage 25 years after treatment. In the last decade, it has been severily escalating. The patient was diagnosed with the diastolic dysfunction of the left ventricle, fibrosis of the aortic and mitral valves and thickening of the pericardium. In childhood cancer survivors, lifelong follow-up is necessary. The majority of cardiac late effects can be discovered with non invasive ultrasound examination.