Biološka označevalca p16 in Ki-67 za opredelitev cervikalne intraepitelijske neoplazije v biopsijskih vzorcih materničnega vratu
Biological markers p16 and Ki-67 for defining cervical intraepithelial neoplasia in biopsy samples of the cervix

Authors

  • Margareta Strojan Fležar Univerza v Ljubljani, Medicinska fakulteta
  • Helena Gutnik Univerza v Ljubljani, Medicinska fakulteta

Keywords:

biological markers, human papillomavirus

Abstract

Biološka označevalca p16 in Ki-67 sta posredna pokazatelja okužbe s humanimi papiloma virusi z velikim tveganjem (HPV-VT), ki so povezani z nastankom predrakavih sprememb na materničnem vratu. V diagnostično težavnih primerih ju lahko uporabimo za razlikovanje cervikalne intraepitelijske neoplazije od morfološko podobnih neneoplastičnih sprememb. Določamo ju lahko s standardnimi imunohistokemičnimi metodami na tkivnih rezinah bioptičnih vzorcev materničnega vratu. Pri vsakdanjem histopatološkem ocenjevanju bioptičnih vzorcev materničnega vratu z dodatnim imunohistokemičnim barvanjem na p16 in Ki-67 največkrat izključimo cervikalno intraepitelijsko neoplazijo visoke stopnje (CIN2 in CIN3), kar prepreči pretirano zdravljenje sprememb na materničnem vratu. Tak diagnostični pristop je uporaben tudi za histopatološko ocenjevanje intraepitelijskih neoplastičnih sprememb endocervikalnega žleznega epitelija.

Abstract (Eng)

The biological markers p16 and Ki-67 are indirect indicators of high-risk human papillomavirus infections (HR-HPV) connected to the formation of precancerous changes in the cervix. In diagnostically more challenging cases, they can be used to distinguish between cervical intraepithelial neoplasia and morphologically similar non-neoplastic changes. They can be determined using standard immunohistochemical methods on tissue slices from cervical biopsy samples. In the daily histopathological evaluation of the cervical biopsy samples with additional immunohistochemical staining for p16 and Ki-67, a high-grade cervical intraepithelial neoplasia (CIN2 and CIN3) is usually ruled out, which prevents excessive treatment of changes in the cervix. Such diagnostic approach can also be used in the histopathological evaluation of intraepithelial neoplastic changes of the endocervical glandular epithelium.

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Published

2012-06-15

How to Cite

Strojan Fležar, M., & Gutnik, H. (2012). Biological markers p16 and Ki-67 for defining cervical intraepithelial neoplasia in biopsy samples of the cervix. Onkologija : Slovenian Journal of Oncology, 16(1), 40–43. Retrieved from https://revijaonkologija.si/Onkologija/article/view/237

Issue

Vol. 16 No. 1 (2012)

Section

Review Article

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