Neurological adverse events of immune checkpoint inhibitors

case report

Abstract

The significant beneficial effect of treatment with immune checkpoint inhibitors is relatively often accompanied by adverse events, of which neurological events are rare but can be life-threatening.
The article presents neurological complications of treatment with immune checkpoint inhibitors. Two given clinical cases describe neurological adverse events with a clinical picture of peripheral nervous system involvement, namely myositis and acute inflammatory demyelinating polyneuropathy.

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Povzetek

Pomembnemu ugodnemu učinku zdravljenja z zaviralci imunskih nadzornih točk so relativno pogosto pridruženi neželeni zapleti, med katerimi so nevrološki redki, a lahko življenje ogrožujoči.
V prispevku so predstavljeni nevrološki zapleti zdravljenja z
zaviralci imunskih nadzornih točk. Podana klinična primera
opišeta nevrološka zapleta s klinično sliko prizadetosti perifernega živčevja, in sicer miozitisom in akutno inflamatorno demielinizirajočo polinevropatijo.