@article{Kos_Serša_2019, title={DNA vaccines for cancer treatment}, volume={23}, url={https://revijaonkologija.si/Onkologija/article/view/418}, DOI={10.25670/oi2019-005on}, abstractNote={<p>DNA vaccination has emerged as a promising immunotherapeutic approach against cancer due to its simplicity, stability, and safety. DNA vaccines for cancer immunotherapy are designed to deliver one or several genes encoding tumor antigens, thereby eliciting an immune response against antigens that play a central role in tumor initiation, progression or metastasis. Despite all advantages, DNA vaccines face challenges in inducing potent antigen-specific immune response in humans, which limits the successful translation from preclinical models to the clinic. Different strategies to enhance immunogenicity of DNA vaccines against tumor antigens are used, for example optimization of plasmid structure, search for new tumor antigens, development of new delivery systems and utilization of molecular adjuvants and immunomodulatory signals. These very promising approaches are employed in numerous clinical trials and hold promise for increasing the immunogenicity of cancer DNA vaccines, enhancing cancer eradication and contributing to easier translation of DNA vaccination into human clinical use.</p>}, number={1}, journal={Onkologija : a medical-scientific journal}, author={Kos, Špela and Serša, Gregor}, year={2019}, month={Jun.}, pages={34–39} }