Priporočila za sistemsko onkološko in radioterapevtsko zdravljenje rakov biliarnega trakta
Recommendations for systemic oncological and radiation treatment of the biliary tract cancers
DOI:
https://doi.org/10.25670/oi2025-008onKeywords:
biliary tract cancers, patients, recommendations, systemic treatment, radiation therapyAbstract
Raki biliarnega trakta so redka in heterogena skupina z naraščajočo incidenco in visoko umrljivostjo. Imajo slabo prognozo s celokupnim preživetjem manj od 1 leta. Nova dognanja o molekularno genetski heterogenosti rakov biliarnega trakta in novi terapevtskih pristopi omogočajo tem bolnikom daljša preživetja in boljšo kvaliteto življenja. V Priporočilih so predstavljena najnovejša priporočila za sistemsko onkološko zdravljenje in radioterapijo te skupine rakov, med katere po mednarodnih propročilih sedaj prištevamo karcinom žolčnika, intrahepatalne holangiokarcinome in ekstrahepatične holangiokarcinome, s perihilarnim holangiokarcinomom in karcinomom distalnega žolčevoda. Priporočila za sistemsko zdravljenje so povzeta in pripravljena na podlagi mednarodnih priporočil, ameriških, National Comprehensive Cancer Network (NCCN) in evropskih, Evropskega združenja za internistično onkologijo – European Society of Medical oncology (ESMO).
Abstract (Eng)
Biliary tract cancers are a rare and heterogeneous group with increasing incidence and high mortality. They have a poor prognosis with an overall survival of less than 1 year. New insights into the molecular genetic heterogeneity of biliary tract cancers and new therapeutic approaches allow these patients to survive longer and have a better quality of life. The Recommendations present the latest recommendations for systemic oncological treatment and radiotherapy of this group of cancers, which, according to international agreements, now include gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with perihilar cholangiocarcinoma and carcinoma of the distal bile duct. The recommendations for systemic treatment are summarized and prepared on the basis of international recommendations, American National Comprehensive Cancer Network (NCCN) and European, European Association for Internal Oncology - European Society of Medical Oncology (ESMO).
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Copyright (c) 2025 Erik Brecelj, Martina Reberšek, Ajra Šečerov Ermenc, Vesna Zadnik, Maja Ebert Moltara, Nežka Hribernik, Peter Korošec, Tanja Mesti, Janja Ocvirk, Franci Anderluh, Marko Boc, Marija Ignjatović, Ana Jeromen, Irena Oblak, Vaneja Velenik, Jelena Azarija, Neva Volk, Nena Golob
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