Tekočinska biopsija pri raku
Liquid biopsy in cancer

Authors

  • Tanja Jesenko Onkološki inštitut Ljubljana, Zaloška cesta 2, 1000 Ljubljana
  • Cvetka Grašič Kuhar Onkološki inštitut Ljubljana, Zaloška cesta 2, 1000 Ljubljana
  • Maja Čemažar Onkološki inštitut Ljubljana, Zaloška cesta 2, 1000 Ljubljana; Fakulteta za vede o zdravju, Univerza na Primorskem, Polje 42, 6310 Izola

DOI:

https://doi.org/10.25670/oi2018-019on

Keywords:

liquid biopsy, cfDNA, ctDNA, circulating tumor cells, exosomes

Abstract

V zadnjih letih smo v onkologiji priča hitremu napredku na področju biopsije telesnih tekočin oz. tekočinske biopsije. Tekočinska biopsija predstavlja analizo vzorca odvzete telesne tekočine (v onkologiji je to običajno kri), v katerem iščemo znake navzočnosti raka. V krvi lahko analiziramo cirkulirajočo prosto/cirkulirajočo tumorsko DNA (cf/ctDNA) iz tumorskih celic, eksosome, ki jih v kri sproščajo tumorske celice, in tudi cirkulirajoče tumorske celice (CTC). V pregledu predstavljamo najnovejša dognanja in raziskave na področju tekočinske biopsije pri raku in poleg uporabnosti izpostavljamo tudi njihove omejitve, ki jih bo treba natančno opredeliti, če bomo želeli to metodo uporabljati v vsakodnevni obravnavi bolnikov.


Abstract (Eng)

Recently, new exciting developments in oncology have been made in the field of liquid biopsies. In liquid biopsy, samples of blood or other body fluids are analyzed for tumor-derived material. Tumor-derived material comprises cell-free circulating tumor DNA (cf/ctDNA), exosomes released by tumor cells, or circulating tumor cells themselves (CTC). In this review, we highlight the studies that summarize the state of the art in the field of liquid biopsy, and also represent the current challenges which should be addressed in the future to successfully implement liquid biopsy in a clinical setting.

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Published

2018-09-09

How to Cite

Jesenko, T., Grašič Kuhar, C., & Čemažar, M. (2018). Liquid biopsy in cancer. Onkologija : A Medical-Scientific Journal, 22(2), 26–31. https://doi.org/10.25670/oi2018-019on

Issue

Vol. 22 No. 2 (2018)

Section

Review Article

License

The journal is published under the terms of the Creative Commons Attribution License CC-BY 4.0. The authors retain the copyright to their work without any restrictions whatsoever.

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