Dedni rak debelega črevesa in danke
Hereditary colorectal cancer
Abstract (Eng)In five to ten percent of patients with colorectal cancer there is a family anamnesis where patients indicate a number of relatives of different generations on one side of the family (mother or father) who were also diagnosed with colorectal cancer and/or related cancers. Such patients are often of a young age and are diagnosed with the disease 10 to 20 years earlier than it is common in the population. These types of cancer are called »hereditary colorectal cancers«. Some patients with hereditary colorectal cancer may be diagnosed with more than one cancer (2). The occurrence of hereditary colorectal cancer is connected to the inheritance of a specific mutation - defect in the hereditary material, therefore a person who inherits this mutation is at a greater risk of developing this disease. Thus, there is a greater probability that a hereditary colorectal cancer will occur in someone who has inherited this genetic change compared with the general population, although it is not certain that the cancer will develop. Inheritance of gene mutations associated with the occurrence of colorectal cancer is very complex and is a feature of several syndromes. We present two most common ones.
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